VLC has basic support for mouse gestures. To activate this add "gestures" to the extraintf list (like this "vlc --extraintf gestures" ) or write "gestures" in the "extra interface modules" field in the configuration window.
You can select which button you want to hold down while using the gestures in the preferences panel.
The following gestures are supported:
* left : Go to previous entry in playlist * right : Go to next entry in playlist * up-right : Enter fullscreen mode * down-right : Quit VLC